PMID: 11321387Apr 26, 2001Paper

Successful immune response to a recombinant hepatitis B vaccine in children after liver transplantation

Journal of Pediatric Gastroenterology and Nutrition
P DucaD D'Agostino

Abstract

Patients who undergo liver transplantation require multifaceted general care, and vaccination has a fundamental role before and after transplantation. The purpose of this study was to provide a prospective evaluation of the immunogenicity of the recombinant vaccine (RV) against Hepatitis B in pediatric patients with liver transplants (TxH) who for different reasons did not receive a pretransplantation vaccine. From June 1996 to December 1999, 47 pediatric patients with liver transplants were vaccinated with RV. Patients older than 1 year of age, in stable condition, and 6 months post-transplantation were included. The vaccination scheme was 0-1 and 6 months, intramuscular 10 microg in less than 30 kg body weight, and 20 microg in more than 30 kg body weight. The nonresponder patients were vaccinated with a booster dose and a double dose 1 to 6 months after the last dose. Responders to titer HBs Ab enzyme immunoassay (EIA) <10 UI/ml were defined as nonresponders, to titer between 10-100 UI/ml as responders, and to higher titer of 100 UI/ml as high responders. The following data were obtained from the 47 patients: mean +/- standard deviation (SD) age at vaccination was 10.76 +/- 5.96 years old and the mean +/- SD post-transplant ...Continue Reading

References

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Citations

Feb 5, 2002·Current Gastroenterology Reports·Debora Kogan-LibermanBenjamin L Shneider
Dec 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lorry G Rubin Infectious Diseases Society of America
Oct 1, 2013·Journal of the American Academy of Dermatology·Lara Wine-LeeAbby S Van Voorhees
May 30, 2013·Infectious Disease Clinics of North America·Jessica Rosen
Aug 21, 2015·Human Vaccines & Immunotherapeutics·Arnaud G L'Huillier, Deepali Kumar
Jun 19, 2009·Journal of the American Academy of Dermatology·Bruce StroberMelodie Young
Mar 10, 2016·Vaccine·Isao MiyairiAkihiko Saitoh
Oct 27, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Danziger-IsakovUNKNOWN AST Infectious Diseases Community of Practice
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Danzinger-IsakovUNKNOWN AST Infectious Diseases Community of Practice
Oct 10, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sushmita BanerjeeAsiri Samantha Abeyagunawardena
Oct 25, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Per Ljungman
Apr 1, 2018·Clinical Transplantation·Hilary Miller-HandleyLara Danziger-Isakov
Dec 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adrienne P GilkesAmanda M Burkhardt

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