Abstract
Prevention and suppression of experimental allergic encephalomyelitis were demonstrated in rats, guinea pigs, and rabbits immunized with allogeneic, but not with syngeneic lymphocytes from susceptible donors sensitized to myelin basic protein (MBP). Donor lymphnode, splenic, or peripheral blood lymphocytes were effective in inducing a state of unresponsiveness to an encephalitogenic challenge in either of the three species. Unresponsiveness was not obtained in recipients immunized with sensitized allogenic lymphocytes and simultaneously challenged with MBP suggesting that a time lapse between immunization and challenge is necessary for the development of protective immunity. Induced in immunized recipients, unresponsiveness was transferred into normal syngeneic recipients with immunoglobulin-G (IgG) isolated from protected donors before challenge. Furthermore, both immunized and IgG recipients failed to develop cell-mediated immunity after challenge with MBP. The results show that prevention and suppression of EAE was mediated by antibodies which inhibited the development of delayed type hypersensitivity to the challenging antigen.
References
Jan 1, 1975·The Journal of Experimental Medicine·D E McFarlinR F Kibler
Jul 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·G A HashimL E Stevens
Jun 10, 1977·Science·G A Hashim
Jan 1, 1979·Journal of Neurochemistry·G A HashimE F Carvalho
Nov 11, 1976·Nature·A Munro, S Bright
Jan 21, 1972·Science·B Benacerraf, H O McDevitt
Oct 1, 1973·The Journal of Experimental Medicine·R M Williams, M J Moore
Oct 1, 1974·Immunochemistry·G A Hashim, R D Sharpe
Mar 1, 1968·Science·S H StoneJ H Goode
Jun 1, 1969·Archives of Biochemistry and Biophysics·E H EylarL V Brown
Feb 1, 1980·Neurochemical Research·G A Hashim
Jan 1, 1957·The Journal of Allergy·J FREUND
Oct 18, 1958·Nature·M W KIES, E C ALVORD
May 13, 1960·Science·J BELL, P Y PATERSON
May 1, 1963·The Journal of Experimental Medicine·P Y PATERSON, S M HARWIN
Jan 1, 1963·International Archives of Allergy and Applied Immunology·M FLAX, B H WAKSMAN
Jan 1, 1960·The Journal of Experimental Medicine·P Y PATERSON
Feb 1, 1977·Neurochemical Research·G A HashimJ C Pierce
Citations
Sep 1, 1990·Journal of Neuroimmunology·M KozovskaI Goranov
Feb 1, 1989·Italian Journal of Neurological Sciences·D GambiA Sbriccoli
Dec 1, 1989·Journal of Neuroimmunology·M StaykovaI Goranov
Jan 25, 1991·Science·H OffnerA A Vandenbark