Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom

The Journal of Allergy and Clinical Immunology
U MüllerK Blaser

Abstract

Specific immunotherapy with honeybee venom (BV) is highly effective, but allergic side effects can occur during treatment. Immunotherapy with peptides containing major T-cell epitopes of the relevant allergen or allergens provides an alternative strategy without these problems. The study investigates the immunologic mechanisms and clinical effects of immunotherapy with T-cell epitope peptides of the major BV allergen, the phospholipase A2 (PLA). Five patients with IgE-mediated systemic allergic reactions to bee stings were treated with a mixture of three T-cell epitope peptides of PLA. Ten patients allergic to BV receiving whole BV immunotherapy served as control subjects. Increasing doses of the peptide mixture, up to a maintenance dose of 100 microg, were administered subcutaneously within 2 months. The patients were then challenged with PLA and 1 week later with a bee sting. The cellular and humoral immune response was measured in vitro. No allergic side effects were caused by the peptide immunotherapy, and all patients tolerated the challenge with PLA without systemic allergic symptoms. Two patients developed mild systemic allergic reactions after the bee sting challenge. After peptide immunotherapy, specific proliferative ...Continue Reading

Citations

Apr 1, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Deepsikha SrivastavaBhanu Pratap Singh
Mar 15, 2002·Current Allergy and Asthma Reports·F Runa AliMark Larché
Mar 15, 2002·Current Allergy and Asthma Reports·Thomas A E Platts-Mills
Mar 16, 2002·Current Allergy and Asthma Reports·Gerald W Volcheck
Mar 29, 2006·Current Allergy and Asthma Reports·Flurina MeilerMübeccel Akdis
Nov 18, 2011·Current Allergy and Asthma Reports·Jay A Lieberman, Anna Nowak-Węgrzyn
Jan 15, 2013·Current Allergy and Asthma Reports·Linda CoxMark Larche
Jun 7, 2013·Current Allergy and Asthma Reports·Melina MakatsoriMoises A Calderon
Sep 3, 2013·Human Immunology·Eugene V RavkovJulio C Delgado
Jun 9, 2005·Molecular Immunology·Eva María GonzálezRosalía Rodríguez
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Udo HerzUrsula Wiedermann
Feb 14, 2004·Methods : a Companion to Methods in Enzymology·Susanne VrtalaRudolf Valenta
Oct 19, 2002·Molecular Aspects of Medicine·Sylvia M Miescher, Monique Vogel
Feb 13, 2001·Trends in Pharmacological Sciences·C Walker, C Zuany-Amorim
Aug 17, 2002·Current Opinion in Immunology·Klaus J Erb, Gisela Wohlleben
Nov 5, 2002·Current Opinion in Immunology·Rudolf Valenta, Dietrich Kraft
Jan 23, 1999·Current Opinion in Immunology·J Rolland, R O'Hehir
Jun 30, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Adrian G Letz, Christopher W Calabria
May 5, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D F Jelinek
Sep 21, 2001·Microbes and Infection·H Groux
Sep 21, 2001·Microbes and Infection·C A Akdis, K Blaser
Sep 21, 2001·Microbes and Infection·H YsselJ Pène
Mar 29, 2001·Trends in Immunology·C A Akdis, K Blaser
Nov 8, 2001·Trends in Immunology·G Wohlleben, K J Erb
Oct 14, 2003·International Immunopharmacology·Imed Ben NasserDaniel Tome
Jun 20, 2000·Allergy·C A Akdis, K Blaser
Jul 9, 2002·Allergy·U R Müller
May 24, 2011·Cellular & Molecular Immunology·C C LeeB L Chiang
Feb 19, 2010·Mucosal Immunology·A RayP Ray
Apr 7, 2005·Nature Medicine·Mark Larché, David C Wraith
Mar 19, 2005·Nature Reviews. Immunology·C M Hawrylowicz, A O'Garra
Sep 26, 2006·Nature Reviews. Immunology·Mark LarchéRudolf Valenta
Jan 22, 2003·Immunology and Cell Biology·Mohan B Singh, Prem L Bhalla
Mar 6, 2002·Clinical and Experimental Immunology·E V SvirshchevskayaV P Kurup
Jun 20, 2001·Immunology·C A Akdis, K Blaser
Nov 13, 2008·The Journal of Experimental Medicine·Flurina MeilerMübeccel Akdis
Oct 26, 1999·Allergy·C A Akdis, K Blaser
Oct 26, 1999·Allergy·U R Müller
Mar 29, 2000·Allergy·L Haugaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.