Successful Implementation of HIV Preexposure Prophylaxis: Lessons Learned From Three Clinical Settings

Current HIV/AIDS Reports
Julia L MarcusStephanie E Cohen

Abstract

The past 3 years have marked a transition from research establishing the safety and efficacy of HIV preexposure prophylaxis (PrEP) to questions about how to optimize its implementation. Until recently, PrEP was primarily offered as part of randomized controlled trials or open-label studies. These studies highlighted the key components of PrEP delivery, including regular testing for HIV and other sexually transmitted infections (STIs), adherence and risk-reduction support, and monitoring for renal toxicity. PrEP is now increasingly provided in routine clinical settings. This review summarizes models for PrEP implementation from screening through initiation and follow-up, focusing on the strengths and weaknesses of three delivery systems: a health maintenance organization, an STI clinic, and a primary care practice. These early implementation experiences demonstrate that PrEP can be successfully delivered across a variety of settings and highlight strategies to streamline PrEP delivery in clinical practice.

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Citations

Nov 20, 2016·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Susanne Doblecki-LewisMichael A Kolber
Mar 16, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kerry A ThomsonUNKNOWN Partners PrEP Study Team
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Jun 29, 2018·Sexually Transmitted Infections·Carys KnapperIrene Parker
Aug 8, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Matthew A SpinelliSusan P Buchbinder
Nov 2, 2018·Home Healthcare Now·Teri Capriotti
Feb 16, 2019·Journal of the International AIDS Society·Douglas KrakowerKenneth H Mayer
Mar 15, 2019·HIV Medicine·Michael BradyIngrid Young
Aug 29, 2019·Journal of the International AIDS Society·Maria N PyraJared M Baeten
Jul 15, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Charlotte-Paige RolleColleen F Kelley
Jan 16, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kevin M WeissSamuel M Jenness
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Aug 16, 2017·Current HIV/AIDS Reports·Jennifer Velloza, Renee Heffron
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Mar 3, 2021·AIDS Care·Chunqing LinYan Li
Jan 9, 2022·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Edith V SullivanAdolf Pfefferbaum

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