PMID: 9551461Apr 29, 1998Paper

Successful induction of tolerance in an epilepsy patient with phenobarbital allergy

Der Nervenarzt
W Fröscher, D Kleinhans

Abstract

We report on a 32-year-old female patient who had had a history of complex partial seizures since the age of 14. Phenobarbital was the most effective anticonvulsant drug in this patient. However, the drug treatment was complicated by a phenobarbital-induced exanthematous eruption. Reintroduction of the phenobarbital some years later resulted in a skin rash again; therefore, treatment with this substance had to be discontinued a second time. Because of the satisfactory antiepileptic efficacy, phenobarbital was introduced a third time using a desensitization procedure with increased oral doses, starting with a dose of 1 mg. After a daily dose of 90 mg phenobarbital, on day 6 an exanthematous eruption appeared. The exanthem disappeared parallel to a dose reduction of phenobarbital and with a gradually increasing dosage up to a maintenance dose of 200 mg. Tolerance to the allergic effect of phenobarbital was preserved and the seizure frequency was significantly reduced by phenobarbital monotherapy with a daily dose of 200-175 mg.

Citations

Feb 3, 2018·Journal of Pharmacy Practice·Robert H Witcher, Michelle M Ramirez

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

The Australasian Journal of Dermatology
Yee J Tai, Mei Tam
Journal of the American Academy of Dermatology
H J HulseboschJ M Lange
Seizure : the Journal of the British Epilepsy Association
S J TavernorS W Brown
© 2022 Meta ULC. All rights reserved