Successful liver transplantation and delivery in a woman with fulminant hepatic failure occurring during the second trimester of pregnancy

Liver International : Official Journal of the International Association for the Study of the Liver
Nicolás JarufeJorge Martínez

Abstract

Severe liver dysfunction occurring during pregnancy is an unusual but dramatic event that poses special technical and ethical issues because it involves two lives. We report the case of a 35-year-old woman with cryptogenic fulminant hepatic failure who underwent successful orthotopic liver transplantation at 22 weeks of pregnancy. After a relatively uneventful post-operative course she delivered a normal offspring at the 27th week of gestation. There were no obstetrical complications and neonatal outcome was excellent. After a year of follow-up, the patient is doing well,and the newborn has exhibited normal psychomotor and weight/height development. This case illustrates the challenge of treating fulminant hepatic failure during pregnancy and demonstrates that liver transplantation is a feasible therapeutic option for treatment of patients with this condition, allowing successful completion of pregnancy.

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Citations

Jan 3, 2014·Case Reports in Obstetrics and Gynecology·Nina KimmichNicole Ochsenbein-Kölble
Dec 12, 2012·Case Reports in Transplantation·Vinaya C MaddukuriMark W Russo
Feb 11, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·A-C Goarin, L Homer
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Jul 22, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Luca TotiGiuseppe Tisone
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Premashis Kar, Anando Sengupta
Dec 15, 2020·World Journal of Transplantation·Ioannis A ZiogasGeorgios Tsoulfas

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