Successful management of adult respiratory distress syndrome (ARDS) after high-dose chemotherapy and peripheral blood progenitor cell rescue by non-invasive ventilatory support

Bone Marrow Transplantation
W RabitschP Kalhs

Abstract

A 34-year-old man suffering from Hodgkin's disease underwent high-dose chemotherapy (CBV) followed by transplantation of autologous peripheral blood stem cells. On day +6 after peripheral blood stem cell transplant (PBSCT) bacterial pneumonia developed. Along with rapid engraftment during stimulation with G-CSF adult respiratory distress syndrome (ARDS) developed within 4 days. High-flow CPAP (continuous positive airway pressure) ventilation via a sealed face-mask was initiated. The patient tolerated the sealed face-mask very well, and CPAP was continuously administered for 4 days, thus avoiding intubation. High-flow CPAP may offer a therapeutic alternative in selected patients with respiratory compromise after PBSCT.

Citations

Apr 10, 2002·Critical Care Medicine·Elie AzoulayBenoît Schlemmer
Oct 28, 2008·Neurological Research·Marc L OttenRobert A Solomon
Nov 3, 2005·Clinics in Chest Medicine·Steve G Peters, Bekele Afessa
Jul 4, 2001·Bone Marrow Transplantation·T R Spitzer
Mar 19, 2009·Pharmacological Reviews·Noboru TodaTomio Okamura

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