Successful Matched Related Bone Marrow Transplantation in a Patient with Autosomal Dominant Interferon Gamma Receptor 1 Deficiency.

Journal of Clinical Immunology
Christa S ZerbeJennifer A Kanakry

Abstract

This is a report of a successful bone marrow transplant in an IFN-γR1 patient with progressive mycobacterial infection. Hematopoietic cell transplant in patients with interferon gamma receptor deficiencies has been fraught with challenges, not the least of which is failure of engraftment and infectious complications. This is a report of a successful hematopoietic cell transplant in an actively infected patient of advanced age. This case report shows successful engraftment and resolution of infection posttransplant using a matched related donor in a single institution. A successful curative HCT despite persistent, disseminated, nontuberculous mycobacterial infection in a patient with AD-IFNγR1 suggests that this approach, while difficult, may be useful in other patients with otherwise refractory disease.

References

May 20, 2009·The Pediatric Infectious Disease Journal·Petra MoilanenUlla M Saarinen-Pihkala
Mar 21, 2013·Journal of Clinical Immunology·H I BaxE P Sampaio
Aug 16, 2016·The Journal of Allergy and Clinical Immunology·Camilia KamounJennifer R Heimall
Apr 7, 2019·Journal of Clinical Immunology·Thomas F MichniackiMark T Vander Lugt
Jun 14, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maura ManionIrini Sereti
Sep 8, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Dimana DimitrovaJennifer A Kanakry

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT00018044
NCT02579967

Related Concepts