PMID: 15218972Jun 29, 2004Paper

Successful micafungin (FK463) treatment of invasive pulmonary aspergillosis in a patient with acute lymphoblastic leukemia in a phase II study

International Journal of Hematology
Shuichi OtaMasahiro Imamura

Abstract

We treated a 52-year-old woman with acute lymphoblastic leukemia (ALL) who developed invasive pulmonary aspergillosis (IPA) as a result of neutropenia following remission-induction chemotherapy. Although serological test results, such as those for platelia and pastrex, were all negative and the serum level of beta-D-glucan was low, Aspergillus DNA was detected in blood by the polymerase chain reaction method. A clinically documented diagnosis of IPA was made on the basis of chest x-rays, computed tomography scan findings, and the detection of Aspergillus DNA. Micafungin (FK463), a candin class antifungal agent, was administered at a dose of 75 to 150 mg/day, because other antifungal agents were not effective. The increase in serum concentration of micafungin was dose-dependent and was accompanied by improvement of symptoms and objective findings. Micafungin was effective for the treatment of IPA in this patient with ALL.

References

May 1, 1994·Journal of Medical Microbiology·K MakimuraH Yamaguchi
Sep 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D W Denning
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·S MatsumotoS Kuwahara
Sep 12, 2000·The Journal of Antimicrobial Chemotherapy·H MikamoT Tamaya
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D CaillotH Guy
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D BuchheidtR Hehlmann
Jun 19, 2002·Seminars in Respiratory Infections·Sofia Perea, Thomas F Patterson
Oct 11, 2003·Lancet·David W Denning

❮ Previous
Next ❯

Citations

May 26, 2009·Revista iberoamericana de micología·Mercedes Catalán-González, Juan Carlos Montejo-González
May 26, 2009·Revista iberoamericana de micología·Miguel Salavert-Lletí, Rafael Zaragoza-Crespo
Apr 1, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P H Chandrasekar, J D Sobel
Mar 26, 2010·The Journal of Antimicrobial Chemotherapy·Melanie W PoundRichard H Drew
Mar 25, 2008·Therapeutics and Clinical Risk Management·Gregory EschenauerPeggy L Carver
Apr 7, 2006·Expert Review of Anti-infective Therapy·Vicki A Morrison
Sep 3, 2013·Expert Review of Hematology·Radhika DasararajuAmitkumar Mehta
Apr 26, 2006·Expert Opinion on Emerging Drugs·Michelle S TurnerJohn R Perfect
May 26, 2007·International Journal of Antimicrobial Agents·George Petrikkos, Anna Skiada
Dec 29, 2006·Pharmacotherapy·Jomy M JosephLarry H Danziger
Feb 1, 2014·The Journal of Infection·D A EnochJ A Karas
Apr 15, 2005·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Aydan IkincioğullariEmel Babacan
Sep 9, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michele I Morris, Mark Villmann
Oct 19, 2013·Expert Review of Anti-infective Therapy·Kim VanstraelenIsabel Spriet
Jan 22, 2005·Current Opinion in Pediatrics·Charalampos Antachopoulos, Thomas J Walsh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.