PMID: 9555798Apr 29, 1998Paper

Successful monotherapy of severe and intractable atopic dermatitis by photopheresis

Journal of the American Academy of Dermatology
H I RichterJ Krutmann

Abstract

Patients with chronic atopic dermatitis can become unresponsive to standard immunosuppressive therapy and thus pose a serious therapeutic problem. Our purpose was to evaluate the therapeutic effectiveness of photopheresis in the management of patients with severe and intractable atopic dermatitis. Photopheresis was used as monotherapy in patients (n = 3) who previously did not respond to treatment with glucocorticosteroids, cyclosporine, phototherapy, or photochemotherapy. Patients were treated at 2-week intervals (total number of treatments = 10). In all patients, photopheresis induced clinical improvement and reduction of elevated serum levels of eosinophil cationic protein and total IgE. Prolongation of the intervals between treatments from 2 to 4 weeks caused worsening in one patient, whereas shortening of treatment-free intervals improved both clinical and laboratory findings. These studies indicate that photopheresis may be used as monotherapy for the treatment of patients with severe atopic dermatitis that has become intractable to standard therapeutic modalities.

References

Jun 1, 1991·Journal of the American Academy of Dermatology·J M Hanifin
Sep 1, 1995·The Journal of Allergy and Clinical Immunology·D Y Leung
Jul 1, 1995·Lancet·J H HorinaP Wolf
Aug 19, 1995·Lancet·G Sunder-PlassmanR Knobler
Jan 1, 1994·Archives of Dermatological Research·B PrinzG Plewig
Jan 1, 1994·Lancet·M GreweJ Krutmann
May 28, 1994·Lancet·J D BosJ H Smitt
Jul 1, 1996·Journal of the American Academy of Dermatology·M J Rothe, J M Grant-Kels
May 1, 1997·Journal of the American Academy of Dermatology·H I RichterJ Krutmann

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Citations

Jan 15, 2009·Archives of Dermatological Research·Thilo Gambichler
Jun 5, 2003·Clinics in Dermatology·Noah S ScheinfeldVincent A DeLeo
Mar 31, 1999·Journal of Dermatological Science·Y Tokura
May 1, 2001·International Journal of Dermatology·G G Russo, C Mullen
Jan 6, 2012·Journal of Allergy·Sonja Alexandra Grundmann, Stefan Beissert
Aug 28, 2009·Actas dermo-sifiliográficas·L Pérez-CarmonaP Jaén-Olasolo
Apr 19, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Jill AdamskiLaura Cooling
May 1, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·P RubegniM Fimiani
May 13, 1999·Journal of the American Academy of Dermatology·G MohlaS Stevens
Dec 30, 2014·Journal of Clinical Apheresis·Zoya KuzminaSteven Z Pavletic
Dec 21, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·R KnoblerU Hillen
May 17, 2012·Expert Opinion on Biological Therapy·Massimo MartinoGiuseppe Bresolin
Jun 21, 2001·Blood Reviews·A Oliven, Y Shechter
Jan 8, 2000·Dermatologic Clinics·R Sidbury, J M Hanifin
Dec 21, 2000·Clinical and Experimental Dermatology·J Krutmann
Apr 10, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T Jung
Sep 2, 2008·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Caroline BuBmannNatalija Novak
Aug 9, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Michael SandKlaus Hoffmann
Jul 13, 2000·Seminars in Cutaneous Medicine and Surgery·R Russell-Jones, S Whittaker
Sep 6, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Peter WolfKlaus Hoffmann
Sep 14, 2018·Frontiers in Medicine·Ara ChoRobert Knobler
Aug 16, 2003·Dermatologic Therapy·Suzan Artik, Thomas Ruzicka
Sep 24, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·R KnoblerH Greinix

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