Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenström's macroglobulinemia with severe pancytopenia

Bone Marrow Transplantation
T UedaT Tamaki

Abstract

We report a 62-year-old male who underwent non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) because of his life-threatening severe pancytopenia due to refractory Waldenström's macroglobulinemia. This therapy was performed safely and he made a marked recovery from his cytopenia that had not been improved with any other therapy. Bone marrow aspirates showed post-transplant mixed chimerism during engraftment, and became completely donor-derived after a series of GVHD symptoms, without subsequent donor lymphocyte infusion. Our results suggest that non-myeloablative allogeneic PBSCT could be a good alternative for patients suffering from multi-drug resistant Waldenström's macroglobulinemia.

References

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Citations

Aug 7, 2002·Blood Reviews·S A JohnsonV Leblond
Nov 7, 2003·The Lancet Oncology·Irene M GhobrialRafael Fonseca
Aug 30, 2011·Bone Marrow Transplantation·M A GertzS M Ansell
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Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Athanasios AnagnostopoulosSergio A Giralt
Nov 9, 2016·Best Practice & Research. Clinical Haematology·Rajshekhar ChakrabortyMorie A Gertz
Jul 5, 2002·Bone Marrow Transplantation·A Anagnostopoulos, S Giralt
Feb 17, 2007·Blood·Arun Vijay, Morie A Gertz

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