Successful outcome with methimazole and lithium combination therapy for propylthiouracil-induced hepatotoxicity.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
M WaseemU M Kabadi

Abstract

To assess the efficacy and safety of combination therapy with methimazole and lithium carbonate in management of severe thyrotoxicosis and propylthiouracil-induced hepatotoxicity. We present a case report of a patient with severe thyrotoxicosis and worsening liver dysfunction after propylthiouracil therapy, and we review the pertinent literature. In a 49-year-old man with severe thyrotoxicosis and propylthiouracil-induced hepatotoxicity, indices of liver function continued to increase despite discontinuation of propylthiouracil treatment. Adjunctive therapy with methimazole and lithium resulted in prompt remission of clinical manifestations and normalization of thyroid hormone indices, as well as a gradual reversal of liver dysfunction. Adjunctive therapy with methimazole and lithium is synergistic in promptly achieving a euthyroid state. Therefore, this combination therapy provides a safe and effective alternative option in patients with thyrotoxicosis associated with propylthiouracil-induced hepatotoxicity.

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Citations

Dec 14, 2004·Thyroid : Official Journal of the American Thyroid Association·Francisca BruscoEugenio Arteaga
Aug 19, 2007·Chemical Senses·Theresa L WhiteSteven L Youngentob
Dec 1, 2009·International Journal of Pediatric Endocrinology·Scott A Rivkees, Donald R Mattison
Jan 27, 2006·PLoS Medicine·Chukwuma Ogbonna Ekpebegh, Naomi Sharlene Levitt
Apr 23, 2011·Thyroid : Official Journal of the American Thyroid Association·Rebecca S Bahn ChairUNKNOWN American Association of Clinical Endocrinologists
Aug 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossMartin A Walter
Jun 28, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rebecca S BahnUNKNOWN American Association of Clinical Endocrinologists

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