Successful pregnancy after high-dose cyclophosphamide, carboplatinum, and taxol with peripheral blood stem cell transplant in a young woman with ovarian carcinoma

Gynecologic Oncology
M V SeidenA F Fuller

Abstract

Both ovarian carcinoma and high-dose chemotherapy tend to preclude future pregnancies. We report a case of a young woman with borderline ovarian carcinoma and invasive tumor implants who underwent surgical debulking with preservation of future fertility followed by carboplatinum, paclitaxel (Taxol), and subsequent high-dose chemotherapy with subsequent peripheral blood stem cell rescue as part of a phase I clinical trial. After a brief period of amenorrhea, the patient had a successful pregnancy that was complicated by a spontaneous abortion in the first trimester. Several months later she conceived and delivered a healthy baby at term. To our knowledge this is the first reported case of pregnancy after high-dose chemotherapy with stem cell transplant in a woman with ovarian carcinoma.

References

Apr 28, 1999·Bone Marrow Transplantation·W Arcese, A P Iori
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G ZanettaC Mangioni

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Citations

May 6, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J WangM J Seckl
Dec 7, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sevtap KilicTuncay Delibasi
Dec 20, 2005·Fertility and Sterility·Wen-Shiung LiouLynn M Westphal
Oct 31, 2003·Expert Opinion on Drug Safety·Maurie Markman

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