Successful Pregnancy and Delivery After Radiation With Ovarian Shielding for Acute Lymphocytic Leukemia Before Menarche

Journal of Pediatric Hematology/oncology
Naoya IshibashiHideo Mugishima

Abstract

Total body irradiation is performed as a preconditioning regimen to inhibit graft-versus-host disease after bone marrow transplantation and to eradicate remaining tumor cells. However, these regimens result in delayed secondary sex characteristics and failure of ovarian function recovery, leading to amenorrhea and infertility. Herein, we report a case of an 11-year-old girl diagnosed with acute lymphocytic leukemia who received induction chemotherapy and prophylactic cranial irradiation. For bone marrow transplantation, she received total body irradiation of 12 Gy with uterine and ovarian shielding at 13 years of age. The patient remained in remission and menarche began at 14 years of age. At 23, she became pregnant and delivered a baby naturally with no abnormalities.

References

May 1, 1992·British Journal of Obstetrics and Gynaecology·H O CritchleyD C Anderson
Oct 22, 2002·American Journal of Obstetrics and Gynecology·Daniel M GreenLeslie L Robison
Jan 4, 2003·Blood·Gérard SociéUNKNOWN Late Effects Working Party of the European Study Group for Blood and Marrow Transplantation
Jun 7, 2005·International Journal of Radiation Oncology, Biology, Physics·W Hamish B WallaceTom W Kelsey

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