Successful pregnancy outcome in a patient with Gaucher's disease and antiphospholipid syndrome

Annals of Hematology
Y ShererP Langevitz

Abstract

Gaucher's disease is characterized by increased incidence of several autoantibodies, but autoimmune phenomena are rare in Gaucher patients. We report the first occurrence of Gaucher's disease and antiphospholipid syndrome in the same patient. A 27-year-old woman with hepatosplenomegaly and thrombocytopenia who was diagnosed as having Gaucher's disease with the genotype 1226G/1226G developed Coombs'-positive hemolytic anemia, recurrent abortions, and a high titer of IgG and IgM anticardiolipin antibodies constituting the diagnosis of antiphospholipid syndrome. A successful pregnancy outcome was achieved by combined therapy with aspirin, low-molecular-weight heparin, prednisone, and enzyme replacement therapy with imiglucerase. The possible pathogenicity of antiphospholipid antibodies found in the sera of many asymptomatic Gaucher patients should be further clarified.

Citations

Jul 16, 2005·Hematology·Ari ZimranDeborah Elstein
Jul 28, 2007·British Journal of Haematology·Derralynn HughesCarla Hollak
Jun 28, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Domenico SantoroArthur H Cohen
Mar 13, 2014·The Journal of Obstetrics and Gynaecology Research·Deborah ElsteinAri Zimran
Mar 30, 2018·Medicine·Damien Le PeilletChristine Serratrice
Oct 9, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Veroniki KomninakaKonstantina Repa

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