Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor.

Rare Tumors
Cristian LolliG Biasco

Abstract

Gastrointestinal stromal tumors (GISTs) are known to be poorly responsive to conventional chemotherapy and historically considered resistant to radiotherapy. In the past the mainstay of GIST treatment was surgery, but the introduction of tyrosine kinase inhibitors (TKIs) imatinib and sunitinib marked the beginning of a new era in the treatment of GIST patients. To date, radiotherapy for GIST has not been administered in clinical practice except for limited palliative settings and there are no clear data on the administration of radiotherapy, alone or in combination with TKIs, with a purely cytoreductive intent. We describe the clinical case of a 48-year-old woman with metastatic GIST treated with external radiotherapy in a critical supraclavicular tumor localization progressively increasing in size with several symptoms and not responsive to systemic TKI therapies. We obtained an initial shrinkage of the mass and subsequent stabilization with an immediate and clear clinical benefit. Although the historical medical literature considered GISTs resistant to radiation therapy, our clinical case suggests this treatment may be appropriate in selected patients.

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Citations

Dec 10, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S HeymannL-M Dourthe
Dec 2, 2014·Journal of Vascular and Interventional Radiology : JVIR·Nils RathmannPeter Hohenberger
Nov 15, 2014·Future Oncology·Maristella SaponaraGuido Biasco
Feb 17, 2017·Case Reports in Oncology·Philippe RochigneuxFrançois Bertucci
Jan 13, 2017·Clinical Sarcoma Research·L GattoM A Pantaleo
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Jan 18, 2018·Chinese Medical Journal·Emine Elif Ozkan
Mar 12, 2015·World Journal of Gastroenterology : WJG·Takeshi GohongiTakesaburo Ogata

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Methods Mentioned

BETA
surgical resection
genotyping

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