Successful reconstruction of an ocular defect resulting from granulomatosis with polyangiitis, following treatment with rituximab

American Journal of Ophthalmology Case Reports
Grace M KennyGeraldine M McCarthy

Abstract

To report a unique case of orbital inflammatory disease which was ultimately diagnosed as granulomatosis with polyangitis (GPA) and thus successfully treated. A 47 year-old man presented with a rapidly progressive necrotic soft tissue mass within the medial antero-superior aspect of the right eyelid and orbit. He also had transient retinal vasculitis in the left. Serology, histology and imaging were atypical of, but consistent with, GPA. He was thus successfully treated with intravenous rituximab followed by reconstruction of the medial eyelid. A high index of suspicion of GPA is required in orbital inflammatory disease, especially when typical diagnostic findings are absent.

Citations

Aug 28, 2021·Journal of Ophthalmic Inflammation and Infection·Caleb C NgEmmett T Cunningham

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Methods Mentioned

BETA
biopsy
ESR

Software Mentioned

GPA

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