Successful renal transplantation following prior bone marrow transplantation in pediatric patients

Pediatric Transplantation
Susan E ThomasJohn C Magee

Abstract

Improving survival rates following pediatric bone marrow transplantation (BMT) will likely result in greater numbers of children progressing to end-stage renal disease (ESRD) because of prior chemotherapy, irradiation, sepsis, and exposure to nephrotoxic agents. Renal transplantation remains the treatment of choice for ESRD; however, the safety of renal transplantation in this unique population is not well established. We report our experience with living related renal transplantation in three pediatric patients with ESRD following prior BMT. Two patients with neuroblastoma and ESRD because of BMT nephropathy, and one patient with Schimke immuno-osseous dysplasia and ESRD because of immune complex mediated glomerulonephritis and nephrotic syndrome. Age at time of BMT ranged from 2 to 7 yr. All patients had stable bone marrow function prior to renal transplantation. Age at renal transplant ranged from 8 to 14 yr. All three patients have been managed with conventional immunosuppression, as no patient received a kidney and BMT from the same donor source. These patients are currently 7 months to 6 yr status post-living related transplant. All have functioning bone marrow and kidney transplants, with serum creatinine levels ranging ...Continue Reading

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Citations

Apr 17, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sangeeta Hingorani
Feb 28, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Pierre CochatLothar Bernd Zimmerhackl
May 15, 2010·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Theresa S Cole, Andrew J Cant
Jan 30, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Osama SafdarJameela A Kari
Aug 21, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kiran Upadhyay, Richard N Fine
Jan 8, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Neeraj SinghGanesh Shidham
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A BolanowskiA D Kirk
Dec 15, 2010·Seminars in Nephrology·Eric P CohenJohn E Moulder
Jan 1, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sangeeta Hingorani
Jul 27, 2005·Bone Marrow Transplantation·J E Kist-van HoltheA J van der Heijden
Sep 18, 2010·Pediatric Transplantation·Nancy BuninKim M Olthoff
Nov 9, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Timothy Bunchman
May 26, 2006·Journal of the American Society of Nephrology : JASN·Sangeeta Hingorani
Aug 14, 2019·Pediatric Transplantation·Oscar K SerranoArthur J Matas
Aug 12, 2014·Advances in Anatomic Pathology·Megan L TroxellNeeraja Kambham
Dec 1, 2012·Current Opinion in Hematology·Robert Sokolic
Nov 9, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Zeynep Yuruk YildirimAhmet Nayir
May 10, 2017·Pediatric Transplantation·Rupesh RainaRolla Abu-Arja

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