Successful rescue therapy with plasmapheresis and intravenous immunoglobulin for acute humoral renal transplant rejection

Transplantation
Nicole B WhiteVivian Tellis

Abstract

Plasmapheresis (PP) and intravenous immunoglobulin (IVIg) remove donor-specific antibodies, a cause of acute humoral rejection (AHR). We describe the use of PP and IVIg as rescue therapy for AHR. The records of 143 renal transplants performed between October 1, 2000 and April 1, 2002 were reviewed. Patients who underwent PP and IVIg therapy for AHR were identified. The data reviewed included age, sex, source of transplant, number of human leukocyte antigen mismatches, transplant number, number of PP and IVIg treatments, dose of IVIg, time of AHR, serum creatinine (SCr) level at AHR, SCr level after PP and IVIg at 3 months, days to achieve 30% decline in SCr, and graft survival. Immunosuppression included basiliximab induction, tacrolimus, and prednisone (+/- sirolimus or mycophenolate mofetil [CellCept, Roche Pharmaceutical, Nutley, NJ]). PP was followed by IVIg infusion. Nine patients were treated for AHR with PP and IVIg. All nine patients demonstrated biopsy-proven AHR. One graft was lost. Mean 3-month and 1-year SCr levels were 1.9 and 1.8, respectively, in the remaining eight patients. AHR in renal transplantation can be effectively treated with PP and IVIg.

Citations

Dec 15, 2010·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Sanjeev BawejaLawrence P McMahon
Aug 7, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas Dechmann-SültemeyerAdina Voiculescu
May 15, 2007·Transplantation·Stanislas FaguerLionel Rostaing
Jan 10, 2006·Seminars in Dialysis·R John Crew, Lloyd E Ratner
Mar 21, 2012·Seminars in Dialysis·Amber P Sanchez, David M Ward
Jul 18, 2009·World Journal of Gastroenterology : WJG·Nassim KamarLionel Rostaing
Nov 19, 2013·International Urology and Nephrology·Yu-Gang ZhaoXiu-Yun He
Sep 10, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anne LemyDaniel Abramowicz
Nov 25, 2011·Expert Opinion on Emerging Drugs·Lars P KihmChristian Morath
Apr 28, 2007·Expert Opinion on Investigational Drugs·Jean-Pierre Venetz, Manuel Pascual
May 3, 2007·Expert Opinion on Pharmacotherapy·Kalathil K SureshkumarRichard J Marcus
Mar 8, 2014·Advances in Chronic Kidney Disease·Ainslie M HildebrandWilliam F Clark
Mar 14, 2012·Transplantation Proceedings·C-F LeeW-C Lee
Nov 29, 2011·Néphrologie & thérapeutique·Patrick Niaudet
Apr 14, 2011·Transplantation Proceedings·O GungorH Toz
Oct 26, 2010·Transplantation Proceedings·M Rodríguez FerreroF Anaya
Apr 21, 2009·Transplantation Proceedings·A M GomesA Cabrita
Jan 13, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Matthew R MorrellRamsey R Hachem
Jul 1, 2008·Transplantation Proceedings·K K SureshkumarR J Marcus
Jul 10, 2007·Seminars in Nephrology·Enver Akalin, Bruno Watschinger
Feb 27, 2016·Current Opinion in Organ Transplantation·Peter T W KimJacqueline G O'Leary
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Solange Moll, Manuel Pascual
Jul 25, 2009·Clinical Transplantation·Muhammad A RafiqEnver Akalin
Mar 30, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C LefaucheurD Glotz
Aug 5, 2008·Clinical Transplantation·Ajda T RowshaniIneke J M Ten Berge
Feb 10, 2009·Clinical Transplantation·Z KaposztasB D Kahan
Apr 22, 2009·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Janka SlatinskaOndrej Viklicky
Feb 20, 2013·Journal of Clinical Apheresis·Elizabeth A K HuntMichael J G Somers
Mar 14, 2012·Journal of Clinical Apheresis·Tahmeena Ahmed, Lisa Senzel
Sep 21, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Sophie Ignace-GirerdEmmanuel Villar
Dec 16, 2010·Tissue Antigens·A A Zachary, H S Eng
May 28, 2014·Journal of Clinical Apheresis·Douglas S Keith
Aug 9, 2005·Current Opinion in Immunology·Ilias I N DoxiadisFrans H J Claas
Feb 8, 2011·Expert Opinion on Pharmacotherapy·Jessica G LucasKalathil K Sureshkumar
Jul 21, 2011·Renal Failure·María José Pérez-SáezPedro Aljama
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Enver Akalin, Manuel Pascual

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