Successful Sequential Treatment with Itraconazole and ALA-PDT for Cutaneous Granuloma by Candida albicans: A Case Report and Literature Review

Mycopathologia
Qing CaiXiu-Li Wang

Abstract

Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues. The patient was treated with itraconazole for 1 month and two sessions of ALA-PDT. After 2 months of follow-up, the patient was cured and has not experienced any recurrence to date. ALA-PDT was well tolerated in this patient with little pain. In general, application of PDT in mycoses is safe and effective in most cases. ALA-PDT is a good choice for inactivation of C. albicans.

References

May 18, 2004·Photodermatology, Photoimmunology & Photomedicine·P G Calzavara-PintonC Zane
Nov 7, 2006·Revista Do Instituto De Medicina Tropical De São Paulo·Felipe Francisco Tuon, Antonio Carlos Nicodemo
Jun 15, 2007·Journal of Photochemistry and Photobiology. B, Biology·Egberto MuninMaricilia Silva Costa
Sep 19, 2007·Archives of Dermatology·Young Jin Kim, You Chan Kim
Jan 6, 2009·Journal of the American Academy of Dermatology·Bianca Maria PiracciniAntonella Tosti
Feb 19, 2010·Lasers in Surgery and Medicine·Jin Woong LeeMyeung Nam Kim
Apr 24, 2010·European Journal of Dermatology : EJD·Yu-Wen YehYu-Fei Chen
Jun 7, 2011·Mycopathologia·Juliana Pereira LyonMaria Aparecida de Resende
Aug 16, 2011·Journal of the American Academy of Dermatology·Yolanda GilaberteAntonio Rezusta
Dec 18, 2013·Photomedicine and Laser Surgery·Yolanda GilaberteAntonio Rezusta
Sep 26, 2015·International Journal of Molecular Sciences·Miri KimHyun Jeong Park

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Citations

Mar 2, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Vanesa Pérez-LagunaMichael R Hamblin

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Datasets Mentioned

BETA
MG764287

Methods Mentioned

BETA
biopsies
PCR
SGA

Software Mentioned

BLAST
ATB FUNGUS

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