PMID: 9537552Apr 16, 1998Paper

Successful surgical outcome in children with sickle hemoglobinopathies: the Duke University experience

Journal of Pediatric Surgery
D M AdamsT R Kinney

Abstract

Surgery in patients with sickle hemoglobinopathies can be problematic because of the potential for sickling events in the perioperative and postoperative period. The authors and others have previously reported successful surgical outcomes using an aggressive erythrocyte transfusion regimen, designed to alleviate anemia and to reduce the percentage of sickle hemoglobin to below 30%. Recently, a randomized trial compared this aggressive regimen with a more conservative transfusion regimen and found no differences in perioperative complications. The incidence of complications, however, was very high in each group (31% to 35%). The authors therefore analyzed retrospectively their surgical experience in children with sickle hemoglobinopathies over the past 10 years to determine the efficacy of an aggressive transfusion regimen and skilled perioperative care in their patient population. A total of 130 surgical procedures were performed on 92 children including 54 cholecystectomies (42%), 23 splenectomies (18%), 12 ENT procedures (9%), 11 central line placements and removals (8%), 7 herniorrhaphies (5%), 7 appendectomies (5%), and 16 miscellaneous operations (13%). The mean age of the children was 10 years (range, 1 to 22 years), and ...Continue Reading

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Citations

Sep 24, 2011·Journal of Pediatric Hematology/oncology·Masanori HayashiCourtney Thornburg
Jun 9, 2016·Journal of the National Medical Association·Nneka C OkoyeDeepika S Darbari
Jun 11, 2005·European Journal of Haematology·Jackie BuckLorna Williamson
Oct 11, 2005·Hematology/oncology Clinics of North America·Jackie Buck, Sally C Davies
Aug 8, 2001·The Journal of Urology·D BrunoJ S Wiener
Aug 29, 2019·American Journal of Hematology·Frederica SchyrrRaffaele Renella
Jul 9, 2003·Paediatric Anaesthesia·Warwick A Marchant, Isabeau Walker
Jan 13, 2010·Journal of Orthopaedic Surgery·German A MarulandaMichael A Mont

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