PMID: 7776674Jun 1, 1995Paper

Successful survival of primates receiving transplantation with "dead," nonbeating donor hearts

The Journal of Thoracic and Cardiovascular Surgery
S R GundryL L Bailey

Abstract

A paucity of donor organs is the principal limitation in human heart transplantation. Prompted by our short-term studies of reanimating "dead" donor hearts in sheep, we applied the same reperfusion modifications in juvenile baboons to determine human applications in an anoxic arrest model (as occurs when non-brain-dead patients are extubated and allowed to die). Ten juvenile baboons (mean weight 3.6 kg) were studied. Five baboons were used as donors. After being anesthetized, donors were pretreated with methylprednisolone (Solu-Medrol), 50% dextrose, nifedipine, and prostaglandin E1 and then paralyzed and extubated. Donors became pulseless at 7 +/- 1 minutes and had electric arrest 9 to 18 minutes after paralysis. The five donors were left undisturbed and warm for 15, 22, 30, 30, and 31 minutes, respectively, after asystole. They were then given 250 ml of 4 degrees C Roe's crystalloid cardioplegic solution via the aortic root and the hearts were explanted into iced Euro-Collins solution. Five baboons served as recipients. After donor harvest, recipients were placed on cardiopulmonary bypass, given prostaglandin E1, and cooled to 18 degrees C; circulatory arrest was instituted and the recipient's heart excised. The donor heart w...Continue Reading

References

May 1, 1992·The Annals of Thoracic Surgery·S R GundryL L Bailey
Oct 23, 1998·Journal of Medical Genetics·E Kirk, L Ades

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Citations

Jan 24, 2007·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Gentaro KatoShunji Sano
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Nov 20, 2020·Transplantation·Laura Anguela-CalvetEva Oliver-Juan

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