Successful testicular sperm extraction (TESE) in spite of high serum follicle stimulating hormone and azoospermia: correlation between testicular morphology, TESE results, semen analysis and serum hormone values in 103 infertile men

Human Reproduction
D JezekW Schulze

Abstract

Spermatozoa recovered from testicular biopsies can be used through intracytoplasmic sperm injection (ICSI) to achieve a pregnancy. To assess the likelihood of successful testicular sperm extraction (TESE) in men suffering from severe oligo- or azoospermia, bilateral biopsy specimens were obtained. Following semi-thin sectioning, the morphology of testicular samples was graded according to a modified Johnsen score. TESE was performed in parallel to this histological examination. The number of isolated spermatozoa was assessed in a semiquantitative way. From 103 patients investigated, 64 (62.1%) showed azoospermia in a preceding semen analysis and 29 (28.2%) patients had sperm concentrations between 0.1 and 1 x 10(6)/ml. In 10 patients who had higher sperm counts, most spermatozoa were non-motile. Spermatozoa could be detected after TESE in the testicular tissue of 49 (77%) azoospermic men. When follicle stimulating hormone (FSH) concentration was normal, most patients had detectable spermatozoa after TESE. Nearly one-third of patients with mildly elevated FSH had no spermatozoa. Thirty-nine percent of patients in whom FSH was elevated to more than twice normal and 50% of patients with grossly elevated FSH had no detectable sperm...Continue Reading

Citations

Sep 21, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N NikolettosK Diedrich
Oct 4, 2002·European Urology·W WeidnerUNKNOWN EAU Working Group on Male Infertility
Nov 29, 2011·Asian Journal of Andrology·Tomomoto Ishikawa
Nov 3, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Kathrein von KopylowChristiane Kirchhoff
Jun 5, 2014·BioMed Research International·Trpimir GolužaDavor Ježek
Apr 10, 2007·Fertility and Sterility·María C LardoneAndrea Castro
Feb 8, 2013·Journal of Assisted Reproduction and Genetics·María C LardoneAndrea Castro
Jul 29, 2010·Genetics and Molecular Research : GMR·A B Oliveira FilhoA P Cedenho
Jul 22, 2011·Molecular Human Reproduction·M C LardoneA Castro
Mar 9, 2010·Human Reproduction·Kathrein von KopylowAndrej-Nikolai Spiess
Feb 3, 2011·Histochemistry and Cell Biology·Viviana KozinaDavor Ježek
Jan 1, 2010·World Journal of Urology·Stefan HinzCarsten Kempkensteffen
Jan 23, 2016·Molecular Human Reproduction·K von KopylowA-N Spiess
May 10, 2011·Systems Biology in Reproductive Medicine·Ferial AslaniMohammad Reza Sadeghi
Jan 5, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M Garcia-LegnameJ Hubert
Jan 21, 2011·The Journal of Urology·Ranjith RamasamyPeter N Schlegel
Jul 14, 2010·Annales de pathologie·Geoffroy RobinValérie Mitchell
Jun 5, 2003·Andrologia·R JohannissonA F Holstein
Sep 21, 2007·International Journal of Urology : Official Journal of the Japanese Urological Association·Akira Tsujimura
Nov 13, 2009·International Journal of Andrology·M C LardoneA Castro
Sep 15, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Feodora StipoljevJadranka Sertić
Dec 3, 2014·Fertility and Sterility·Boback M BerookhimPeter N Schlegel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.