Successful therapeutic splenectomy in an HIV patient with relapsing visceral leishmaniasis

International Journal of STD & AIDS
D Alon, M Chowers

Abstract

A 43-year-old HIV-positive Ethiopian immigrant presented with persistent diarrhoea, hepatosplenomegaly and pancytopaenia. Visceral leishmaniasis was diagnosed by multiple gastrointestinal tract biopsies. Blood polymerase chain reaction (PCR) was positive for Leishmania donovani. Despite highly active antiretroviral therapy (HAART) and multiple courses of antileishmanial treatments, including liposomal amphotericin and sodium stibogluconate, the patient had multiple relapses. CD4 counts remained at 40-60 cells/µL although viral loads were undetectable. Splenectomy resulted in resolution of the patient's pancytopaenia and in rising CD4 levels, which enabled a long-lasting remission.

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Citations

Jul 13, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·T J Wilhelm
Nov 30, 2018·Frontiers in Cellular and Infection Microbiology·Micely d'El-Rei HermidaWashington L C Dos-Santos
Feb 25, 2021·Pathogens and Global Health·Yulia Treister-GoltzmanRoni Peleg
Mar 25, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Marcos Adriano Garcia CamposMônica Elinor Alves Gama

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Methods Mentioned

BETA
biopsies
PCR
biopsy

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