Successful therapy of the prostaglandin defect "Wien-Hietzing" (lack of platelet high-affinity binding sites for prostaglandin I2)

Prostaglandins
G SteurerH Sinzinger

Abstract

Some years ago we detected a lack of platelet high-affinity PGI2 binding sites in a 10 year-old girl who presented to the outpatient unit with clinical symptoms and signs of acute popliteal artery occlusion. We named this new defect in the prostaglandin system "Wien-Hietzing". Acute surgery was successful. On the basis of earlier findings that aspirin is able to sensitize platelets to the action of PGI2 and produce beneficial changes in platelet sensitivity, we decided to treat this girl with a daily dosage of 20 mg aspirin orally. Repeated control examinations during the total follow-up period of about 6 years revealed normalized platelet sensitivity and normalized receptor behaviour. The girl is symptom-free to date. It is concluded that this prostaglandin defect may be successfully treated with long-term, low-dose aspirin administration.

References

Jul 1, 1986·Chest·O C BurghuberK Silberbauer
Apr 1, 1986·Seminars in Thrombosis and Hemostasis·H Sinzinger
May 7, 1981·The New England Journal of Medicine
Aug 1, 1963·The Journal of Physiology·G V BORN, M J CROSS

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Citations

Sep 24, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Rosemarie A ReiterHelmut Sinzinger

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