PMID: 2111746Mar 1, 1990Paper

Successful treatment by chemotherapy for acromegaly associated with ectopic growth hormone releasing hormone secretion from a carcinoid tumour

Clinical Endocrinology
P E HarrisG M Besser

Abstract

Acromegaly secondary to the secretion of ectopic growth hormone releasing hormone (GHRH) is rare. We have documented the presentation and unusual clinical course of a patient with a disseminated GHRH-secreting bronchial carcinoid tumour associated with acromegaly over a 17-year period. Recurrent widespread metastatic lesions have been treated over a 10-year period by repeated cycles of the nitrosourea CCNU and 5-fluorouracil with evidence of tumour regression and reduction of circulating growth hormone (GH) and urinary 5HIAA excretion. This cytotoxic regimen, which has been well tolerated, may prove valuable in the management of disseminated carcinoid tumours.

References

Jan 1, 1979·The Journal of Clinical Endocrinology and Metabolism·M Saeed uz ZafarL A Frohman
Jul 1, 1976·Clinics in Endocrinology and Metabolism·S A Hashim, K Porikos
Jul 1, 1977·Cancer·G W Mitchell, A S Glicksman
Aug 1, 1988·The Journal of Clinical Endocrinology and Metabolism·S MelmedL A Frohman
Feb 1, 1987·Australian and New Zealand Journal of Medicine·D G CarrollJ M Polak
Feb 1, 1974·The Journal of Clinical Endocrinology and Metabolism·F T Dabek
Oct 1, 1981·The Journal of Clinical Endocrinology and Metabolism·S A LevestonW H Daughaday
Mar 1, 1983·Cancer·G N HortobagyiF Schell
Jun 1, 1962·Thorax·E D WILLIAMS, L R CELESTIN

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Citations

Sep 18, 2012·Endocrine·Ali A GhaziOdelia Cooper
Oct 1, 2004·The Journal of Thoracic and Cardiovascular Surgery·Kalliopi AthanassiadiIon Bellenis
Apr 1, 1993·Clinical Endocrinology·J D WalkerD G Lowe
Jun 8, 2004·Endocrine Reviews·Gregory A KaltsasAshley B Grossman
Feb 1, 1995·Psychological Reports·J P Rushton
Jun 1, 1991·Journal of Endocrinological Investigation·R AttanasioP G Chiodini
Aug 24, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Laurence KatznelsonUNKNOWN American Association of Clinical Endocrinologists
Jan 1, 1993·Journal of Endocrinological Investigation·M LosaK von Werder

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