Successful treatment by mycophenolate mofetil in a patient with focal segmental glomerulosclerosis associated with posterior reversible encephalopathy syndrome

CEN Case Reports
Masafumi TentaJun Wada

Abstract

It has been reported that cyclosporine A (CsA) treatment may be associated with posterior reversible encephalopathy syndrome. We report a 16-year-old man who exhibited nephrotic syndrome and posterior reversible encephalopathy syndrome. Intensive antihypertensive therapy restored him to consciousness. Renal biopsy revealed that he suffered from focal segmental glomerulosclerosis. Although he was treated with prednisolone and low-density lipoprotein apheresis therapy, his proteinuria remained at high level. Then, mycophenolate mofetil (MMF) with less influence on vessel endothelium compared with CsA and tacrolimus was administered. Soon after, he reached remission of nephrotic syndrome without recurrence of posterior reversible encephalopathy syndrome. This is the first case that a young patient of focal segmental glomerulosclerosis with posterior reversible encephalopathy syndrome achieved a complete remission by MMF treatment without recurrence of posterior reversible encephalopathy syndrome. MMF may be effective for young patients of focal segmental glomerulosclerosis especially with clinical condition of vascular endothelial damage such as posterior reversible encephalopathy syndrome.

References

Jun 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S FujimotoK Tanaka
Feb 22, 1996·The New England Journal of Medicine·J HincheyL R Caplan
Dec 21, 2000·Postgraduate Medical Journal·R K Garg
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M IkedaK Anbo
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Masaru NakayamaSatoru Fujimi
Sep 25, 2003·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Hiroshi MasudaHiroshi Mori
Apr 15, 2005·International Immunopharmacology·Yanfei HuangLeishi Li
Nov 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lakshmanan Senthil NayagamVivekanand Jha
Dec 11, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Weixin HuLeishi Li
Feb 9, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kenji IshikuraMasataka Honda
Feb 15, 2011·Journal of Nephrology·Tahar T G Gargah, Mohamed Rachid Lakhoua
May 19, 2011·Seminars in Neurology·Steven K Feske
Aug 2, 2011·Nature Medicine·Changli WeiJochen Reiser
Sep 8, 2011·Advances in Chronic Kidney Disease·Jeremy KiffelHoward Trachtman
Oct 7, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jutta GellermannUwe Querfeld
Dec 6, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Ayu OgawaHirofumi Makino
Dec 19, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pietro A Canetta, Jai Radhakrishnan

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Citations

Jan 10, 2018·The Journal of International Medical Research·Magdalena StârceaIngrith Miron
Aug 25, 2017·International Urology and Nephrology·Cristina GavriloviciMagdalena Stârcea

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