Successful treatment by tocilizumab without steroid in a very severe case of TAFRO syndrome

CEN Case Reports
Tamami FujikiRyoichi Ando

Abstract

Successful use of tocilizumab (TCZ) to treat TAFRO syndrome has recently been reported. In those cases, TCZ was used with steroid. We present herein the case of a 59-year-old man with very severe TAFRO syndrome who was successfully treated using TCZ without steroid. He showed rapidly progressive anasarca, acute renal failure and very severe thrombocytopenia. We initially used steroid, but its efficacy was limited. Moreover, steroid use had to be stopped as soon as possible, because hemorrhagic shock developed due to severe duodenal ulcer. After overcoming infections (about 40 days after stopping steroid), administration of TCZ was started and the patient was discharged in clinical remission.

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Citations

May 17, 2018·CEN Case Reports·Toshikazu OzekiShoichi Maruyama
Apr 21, 2018·American Journal of Hematology·Sheila K PiersonDavid C Fajgenbaum
Jan 18, 2018·Modern Rheumatology·Matthew B Carroll
Sep 24, 2020·Annals of Hematology·Mitsuhiro AkiyamaTsutomu Takeuchi
Aug 1, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Takashi YamaguchiNaomi Shimizu

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