Successful treatment of a patient with posthepatitic severe aplastic anemia with bolus methylprednisolone

Japanese Journal of Medicine
S TohdaN Aoki

Abstract

A 31-year-old female developed severe aplastic anemia following acute non-A non-B hepatitis. Because of the impossibility of bone marrow transplantation, bolus methylprednisolone therapy was done. Soon after the therapy, pancytopenia improved. She has since taken mepitiostane and no longer needs blood transfusions. Good response to the immunosuppressive therapy suggests that the pathogenesis of this anemia is related to the immune system. In vitro culture demonstrated that the patient's serum contained a factor which suppressed hematopoietic activity, possibly gamma-interferon.

Citations

Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arun R RaoSeema S Ahuja

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