Successful treatment of acquired hemophilia A with recombinant porcine factor VIII

Medizinische Klinik, Intensivmedizin und Notfallmedizin
K Trautmann-GrillU Platzbecker

Abstract

Acquired hemophilia A is a rare, potentially life-threatening disease resulting from autoantibodies against coagulation factor VIII. We report the case of a patient with acquired hemophilia A and severe bleeding after incision of a peritonsillar abscess. Treatment with high dose factor VIII and recombinant activated factor VII failed to control bleeding. However, a single infusion of recombinant porcine factor VIII stopped bleeding efficiently and resulted in measurable factor VIII levels.

References

Feb 5, 2013·British Journal of Haematology·Douglas W Sborov, George M Rodgers
Jan 28, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·R Kruse-JarresB Ewenstein
Aug 12, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·M D TarantinoM Sholzberg

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