Successful Treatment of Aluminium Phosphide Poisoning by Extracorporeal Membrane Oxygenation

Basic & Clinical Pharmacology & Toxicology
Hossein Hassanian-MoghaddamRoxana Sadeghi

Abstract

Aluminium phosphide (ALP) is one of the most commonly used pesticides worldwide with high mortality rates. Cellular damage and cardiorespiratory failure are the most common causes of mortality and morbidity after poisoning. It is supposed that giving enough time to the patient to survive, the most critical hours after exposure may help the cardiovascular system to recover itself and save the patient's life. During a training workshop for medical extracorporeal membrane oxygenation (ECMO), a 28-year-old ALP-poisoned male was referred to us. Fifty minutes after admission, he developed hypotension and bradycardia and was transferred to ICU. On the second venous blood gas, he had severe metabolic acidosis. After starting the patient on the routine treatment of ALP poisoning, he was a candidate for veno-arterial (VA) ECMO. After three days, lactate level decreased and his general condition improved. On day four, the patient was completely separated from the ECMO machine with acceptable echocardiography and ejection fraction of 40%. One day later, he was extubated, sent to the ward and subsequently discharged in good condition. We suggest this method of treatment for severe ALP poisoning as well as any other poisoning that causes cel...Continue Reading

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Citations

Feb 24, 2016·Basic & Clinical Pharmacology & Toxicology·Mohammad MashayekhianShahin Shadnia
Aug 9, 2016·Medicine·Hossein Hassanian-Moghaddam, Nasim Zamani
Oct 18, 2016·Arhiv za higijenu rada i toksikologiju·Behrooz Hashemi-DomenehAli Ostadi
Feb 6, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Maryam Vasheghani FarahaniSayed Mahdi Marashi
Feb 1, 2018·Cardiovascular Toxicology·Narges-Sadat ZahedNasim Zamani
Jul 11, 2018·Arhiv za higijenu rada i toksikologiju·Jafar AhmadiSomayyeh Karami-Mohajeri
Oct 5, 2018·Arhiv za higijenu rada i toksikologiju·Nasim ZamaniSakine Ebrahimi
Mar 12, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Bishav MohanBhupinder Singh
Jul 20, 2019·Expert Opinion on Drug Metabolism & Toxicology·Omid MehrpourPatrick Ng
Mar 5, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·A K PannuD P Dhibar
Sep 15, 2019·Environmental Science and Pollution Research International·Abeer A ShetaNehad H Gad
Oct 29, 2018·Journal of Medical Case Reports·Achyut SharmaAnup Ghimire

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