Successful Treatment of Behçet's Disease Associated with Acute Myeloid Leukemia with Myelodysplasia-related Changes Using Azacitidine and Tacrolimus before Allogeneic Hematopoietic Stem Cell Transplantation

Internal Medicine
Yukinori NakamuraYukio Tanizawa

Abstract

The coexistence of acute myeloid leukemia (AML) with Behçet's disease (BD) is rare. The optimum treatment for AML-associated BD has not been established. We herein report a patient with BD who developed AML with myelodysplasia-related changes. Induction chemotherapy caused complete remission of the AML but worsened the BD. Thereafter, AML was treated with azacitidine. The BD was steroid-dependent. Tacrolimus was added, which improved the BD. The patient underwent allogeneic hematopoietic stem cell transplantation (HSCT) and remains in complete remission for both diseases. Allogeneic HSCT was found to be a potent therapeutic option for AML-associated BD. In addition, azacitidine and tacrolimus were shown to be a suitable bridging regimen before HSCT.

References

Mar 14, 2009·Lancet·James L M FerraraErnst Holler
Jun 9, 2009·Inflammatory Bowel Diseases·Kayoko MatsumuraTsutomu Chiba
Feb 19, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Taiga NishihoriTeresa Field
Apr 13, 2015·International Journal of Hematology·Muhammad Omer Jamil, Shin Mineishi
Jun 13, 2015·Seminars in Immunopathology·Ahmet Gül

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Citations

Apr 1, 2019·Best Practice & Research. Clinical Haematology·Prajwal C Boddu, Amer M Zeidan
Sep 9, 2020·Seminars in Arthritis and Rheumatism·Anne Laure RoupieUNKNOWN On behalf MINHEMON (French Network of dysimmune disorders associated with hemopathies) and SNFMI.

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BETA
MDS

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