Successful Treatment of Catastrophic Antiphospholipid Antibody Syndrome Associated with MALT Lymphoma by Autologous Hematopoietic Stem Cell Transplantation

Internal Medicine
Satoko OkaMasaharu Nohgawa

Abstract

A 37-year-old woman with extranodal marginal-zone lymphoma was admitted with a fever, hemiplegia, and severe dyspnea after chemotherapy. Catastrophic antiphospholipid antibody syndrome (CAPS) was suspected based on the histopathological confirmation of small-pulmonary vessel occlusion, evidence of the involvement of three organs, and elevated lupus anticoagulant assay results in a short time span. The patient responded to the initial treatment. One month later, the CAPS and lymphoma relapsed, and the patient underwent autologous hematopoietic stem cell transplantation. Complete remission of the lymphoma has been successfully maintained, and the condition of the patient has remained stable for two years with no further evidence of thrombosis.

References

Feb 26, 1999·Bone Marrow Transplantation·J I OlallaA Zubizarreta
Apr 16, 2002·Arthritis and Rheumatism·Ricard CerveraUNKNOWN Euro-Phospholipid Project Group
Aug 2, 2003·Lupus·R A AshersonUNKNOWN Catastrophic Antiphospholipid Syndrome Registry Project Group
Apr 23, 2004·Leukemia & Lymphoma·Jennifer R BrownArnold S Freedman
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Robert Eisenberg, Daniel Albert
Dec 2, 2006·Autoimmunity Reviews·W MiesbachUNKNOWN Members of CAPS Registry Group
Nov 6, 2007·Seminars in Arthritis and Rheumatism·Ronald A AshersonRicard Cervera
Dec 3, 2008·Clinical Reviews in Allergy & Immunology·Wolfgang Miesbach
Dec 10, 2013·Hematology·Wendy Lim
Dec 21, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A H MeyerC W Scholz

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Citations

Jul 8, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Smith KungwankiattichaiTheera Ruchutrakool

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Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

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