Successful treatment of cepacia syndrome with a combination of intravenous cyclosporin, antibiotics and oral corticosteroids

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
Francis J GilchristA M Jones

Abstract

Burkholderia cepacia complex (BCC) is a group of 17 closely related bacterial species that can cause pulmonary infection in patients with cystic fibrosis (CF). The clinical manifestations of BCC infection are varied but can include cepacia syndrome, which is a rapidly progressing necrotising pneumonia with an almost universally fatal outcome. We report the case of a 38 year old man, known to have chronic infection with the ET12 strain of Burkholderia cenocepacia who developed cepacia syndrome 26 years after initial infection. Aggressive treatment with a combination of 4 intravenous antibiotics, oral corticosteroids and cyclosporin brought about clinical, radiological and biochemical resolution of his cepacia syndrome. This case highlights the possible role of cyclosporin in the treatment of cepacia syndrome.

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Citations

Mar 11, 2016·Annals of the American Thoracic Society·Aly M MohamedNina M Clark
Sep 12, 2015·Case Reports in Infectious Diseases·Naomi Hauser, Jose Orsini
Mar 2, 2013·Current Opinion in Pulmonary Medicine·Oana CiofuNiels Høiby
Nov 21, 2020·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Joshua W BranstetterClaudette Poole
Apr 23, 2021·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·C OlceseC Castellani

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