PMID: 20647659Jul 22, 2010Paper

Successful treatment of dwarfism secondary to long-term steroid therapy in steroid-dependent nephrotic syndrome

Internal Medicine
Linlin SunChanglin Mei

Abstract

Prolonged steroid therapy is generally used for steroid-dependent nephrotic syndrome in pediatric patients. However, dwarfism secondary to a long-term regimen and its successful reverse is rarely reported. The underlying mechanism of dwarfism is still poorly understood, as both long-term steroid use and nephrotic syndrome may interact or independently interfere with the process of growth. Here, we present a 17-year-old patient with dwarfism and steroid-dependent nephrotic syndrome and the successful treatment by recombinant human growth factor and cyclosporine A with withdrawal of steroid. We also briefly review the current understanding and the management of dwarfism in pediatric patients with nephrotic syndrome.

References

Sep 1, 1996·Endocrinology and Metabolism Clinics of North America·A Spagnoli, R G Rosenfeld
Jul 27, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·G KlausO Mehls
Aug 7, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Feng Dong, Jun Ren
Jun 22, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M HodsonNarelle S Willis
Dec 17, 2005·The Journal of Pediatrics·Joyce A M EmonsJan M Wit
Jan 20, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jens DrubeJochen H H Ehrich
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May 31, 2007·The Journal of Clinical Endocrinology and Metabolism·Susanne BechtoldHans Peter Schwarz
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