PMID: 9175029Jan 1, 1997Paper

Successful treatment of early secondary myelofibrosis in SLE with IVIG

Lupus
A AharonY Shoenfeld

Abstract

Myelofibrosis has been reported as a rare cause of pancytopenia in patients with autoimmune diseases. We describe a 54y old female patient who was admitted with severe anemia subsequently found to be due to marrow fibrosis. During the course of her hospitalization, relying both on her clinical symptoms as well as the results of a wide range of laboratory tests and diagnostic procedures, the diagnosis of systemic lupus erythematosus was established. The patient was treated with high dose steroids, but improvement of her clinical symptoms as well as normalization of her peripheral blood count were achieved only after high dose intravenous therapy with gamma globulin (IVIG) was instituted. Along with the improvement in the peripheral blood parameters normalization of the bone marrow architecture was recorded on a repeated bone marrow biopsy. IVIG therapy should be considered in extreme cases of bone marrow suppression in SLE.

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Citations

Apr 20, 2001·Arthritis and Rheumatism·R W McMurray
Jun 24, 2009·Clinical Reviews in Allergy & Immunology·Ziv Paz, Yehuda Shoenfeld
Feb 6, 2002·Springer Seminars in Immunopathology·L RauovaY Shoenfeld
Apr 4, 2000·European Journal of Internal Medicine·S Durupt Vital Durand D
Oct 18, 2000·Transfusion Science·E Rewald
Feb 25, 2010·Rheumatology·Prashantha M Vaitla, Elizabeth M McDermott
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Oct 12, 2012·Autoimmune Diseases·Scott E Wenderfer, Trisha Thacker
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May 27, 2004·Leukemia & Lymphoma·Juergen ThieleAnnette Schmitt-Graeff
Jan 30, 2014·International Reviews of Immunology·Simonetta SalemiRaffaele D'Amelio
Oct 23, 2002·Leukemia & Lymphoma·Eduardo Arellano-RodrigoFrancisco Cervantes
Oct 1, 2015·Leukemia & Lymphoma·Victoria K TangCristhiam M Rojas Hernandez
May 9, 2001·Leukemia & Lymphoma·E KissG Szegedi
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Dec 21, 2004·Seminars in Arthritis and Rheumatism·Hedi OrbachYehuda Shoenfeld
May 11, 2000·Seminars in Arthritis and Rheumatism·Y LevyY Shoenfeld

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