PMID: 2107645Jan 1, 1990Paper

Successful treatment of flecainide (Tambocor) poisoning--effect of hemodialysis/hemoperfusion?

Zeitschrift für Kardiologie
E DirksW Hager

Abstract

After suicidal ingestion of 3 g flecainide a 34-year-old woman showed somnolence, cerebral convulsion, disturbances of atrioventricular and intraventricular conduction and ventricular asystole. The maximum flecainide plasma level was 4900 ng/ml; this level is extremely high and exceeds the maximum therapeutic level by five times. After initial cardiopulmonary resuscitation and stabilization by intensive care treatment we performed a combined hemodialysis/hemoperfusion therapy (with activated charcoal). This procedure led to a rapid decrease of flecainide plasma levels and simultaneous improvement of ECG-alterations. The initial decrease in flecainide plasma levels during extracorporeal elimination occurred much quicker (4.5-8.5 h plasma halflife) than the spontaneous decrease rate of flecainide in humans (12-20 h plasma half-life). We conclude that, perhaps, hemodialysis/hemoperfusion therapy is an efficient method for decreasing toxic plasma levels of flecainide and for improvement of the clinical course of this intoxication.

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Related Papers

International Journal of Clinical Pharmacology, Therapy, and Toxicology
E BockG Heinemeyer
Journal of Toxicology. Clinical Toxicology
C KöppelG Heinemeyer
Klinische Wochenschrift
R WurzbergerJ U Becker
Deutsche medizinische Wochenschrift
S TrösterH P Schuster
Intensive Care Medicine
F AlderfliegelR J Kahn
© 2021 Meta ULC. All rights reserved