Successful Treatment of Hemophagocytic Lymphohistiocytosis Associated with Low-risk Myelodysplastic Syndrome by Azacitidine

Internal Medicine
Shinya DaitokuMika Kuroiwa

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome that occurs as a complication in many clinical settings. Malignancy-associated HLH develops in patients with hematopoietic neoplasms, particularly in those with lymphoma, and its development in those with myelodysplastic syndrome (MDS) is uncommon. We herein report a case of HLH in a patient with low-risk MDS that was successfully treated with azacitidine. The prevalence of immune abnormalities among MDS patients and the immune effects of azacitidine have recently been elucidated, suggesting that MDS-associated HLH occurs as a result of immune impairment, and azacitidine improves this condition by restoring the immune system.

References

Sep 21, 2001·British Journal of Haematology·M AricòL Moretta
Aug 29, 2006·Pediatric Blood & Cancer·Jan-Inge HenterGritta Janka
Dec 19, 2007·Pediatric Blood & Cancer·Carl E AllenKenneth L McClain
Dec 17, 2009·Hematology·Alexandra H Filipovich
Apr 10, 2010·Haematologica·Valentina CeticaMaurizio Aricò
Sep 8, 2010·International Journal of Hematology·Takahiro TsujiHiroyuki Tsuda
Feb 3, 2012·European Journal of Haematology·Claudio Fozza, Maurizio Longinotti
Sep 8, 2012·Advances in Experimental Medicine and Biology·Elizabeth A Griffiths, Steven D Gore
Mar 26, 2013·Oncoimmunology·Kristoffer Evebø SandAstrid Olsnes Kittang
May 25, 2013·Blood·Toru Takahashi, Masafumi Matsugama
Mar 12, 2015·Blood·Alison M Schram, Nancy Berliner
Jun 18, 2016·International Journal of Molecular Sciences·Andreas GlenthøjKirsten Grønbæk
Jun 23, 2016·Clinical Epigenetics·Jeannine DieschKatharina S Götze

❮ Previous
Next ❯

Citations

Nov 17, 2020·Frontiers in Pediatrics·Holger HauchChristoph Neuhäuser

❮ Previous
Next ❯

Methods Mentioned

BETA
MDS
biopsy
flow cytometry

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medicine and Health, Rhode Island
Peter Rintels, Sundarsesan Sambandam
Critical Care : the Official Journal of the Critical Care Forum
Rafal MachowiczWieslaw Wiktor-Jedrzejczak
International Journal of Hematology
Takahiro TsujiHiroyuki Tsuda
Ryōikibetsu shōkōgun shirīzu
S Nomura, S Fukuhara
© 2022 Meta ULC. All rights reserved