Successful treatment of herpes simplex virus (HSV) recurrent genital infection with recombinant human (rh) granulocyte-macrophage colony stimulating factor (GM-CSF): a case report

Immunopharmacology and Immunotoxicology
M AltamuraE Jirillo

Abstract

In the present work, we describe the treatment with rhGM-CSF of a woman affected by HSV recurrent genital infection and not responsive to specific antiviral therapy. The therapeutic regimen consisted of a subcutaneous administration of 300 mg/day of rhGM-CSF for six days. Before treatment with rhGM-CSF, polymorphonuclear cell and monocyte functional capacities and the antibacterial activity exerted by T cells were profoundly depressed. After treatment, a normalization of immune functions and a progressive disappearance of clinical manifestations were observed.

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Citations

Aug 18, 2000·Immunopharmacology and Immunotoxicology·A PratelliC Buonavoglia
Feb 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lars BellnerKristina Eriksson

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