Successful treatment of IgA nephropathy in association with low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue type

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
S K MakA K Wong

Abstract

Kidney and the urogenital tract are among the various mucosal sites involved in mucosa-associated lymphoid tissue (MALT) lymphoma. We report a case with simultaneous onset of crescentic immunoglobulin (Ig) A nephropathy and gastrointestinal low-grade B-cell lymphoma of the MALT type with kidney infiltration. M-component of IgM lambda was detected in the serum, and the renal biopsy specimen showed monotypic lambda light chain staining in the lymphoma cells but not the glomeruli. The heavy proteinuria and impaired creatinine clearance returned to normal, and microscopic hematuria disappeared 20 months after treatment with chlorambucil as single-agent chemotherapy. This coincided with a complete resolution of the gastric and renal lymphoma infiltration. The close association of both the onset and successful outcome of the two entities thus support their possible causal relationship, and we discuss the possibility of an association of the disturbance of the MALT by the lymphoma cells with the pathogenesis of IgA nephropathy.

Citations

May 20, 2011·International Urology and Nephrology·Rahil KasmaniDeepak Malhotra
Jul 31, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C CherubiniT Faraggiana
Aug 8, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sibylle von VietinghoffRalph Kettritz
Jan 5, 2008·Clinical and Experimental Nephrology·Osamu MotoyamaKikuo Iitaka
Jan 24, 2006·Clinical Rheumatology·Shuang Ye, Cheng-de Yang
Nov 13, 2019·BMJ Case Reports·Amali SamarasingheAron Chakera
Dec 14, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Tara K SigdelRichard A Lafayette
Aug 18, 2015·International Cancer Conference Journal·Tomoyuki MakinoAtsuhiro Kawashima
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Jan 5, 2006·Archives of Pathology & Laboratory Medicine·Libo QiuJames A Strauchen
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