PMID: 19915299Nov 17, 2009Paper

Successful treatment of KIT D816V-positive, imatinib-resistant systemic mastocytosis with interferon-alpha

Internal Medicine
Chikamasa YoshidaYoshito Sadahira

Abstract

We describe a case of systemic mastocytosis associated with myelodysplastic syndrome. The bone marrow showed multifocal clusters of mast cells and myeloid dysplasia. Sequencing of the KIT DNA revealed a point mutation at codon 816 including a substitution of valine for aspartic acid (D816V). The patient's tumor did not respond to imatinib; however, interferon-alpha reduced the bone marrow mast cells and serum total tryptase. The patient remains alive at one year after the diagnosis without disease progression.

References

Aug 21, 2001·Clinical Pharmacokinetics·C L DeVane, C B Nemeroff
Apr 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael W N DeiningerBrian J Druker
Dec 29, 2004·Leukemia & Lymphoma·Peter ValentDean D Metcalfe
Aug 27, 2005·Clinical Pharmacokinetics·Bin PengHorst Schran
May 10, 2006·Advances in Immunology·Jamie Robyn, Dean D Metcalfe
Aug 8, 2008·Blood·Dean D Metcalfe

❮ Previous
Next ❯

Citations

Jun 2, 2011·The American Journal of the Medical Sciences·Didem OzdemirTomris Erbas
Dec 18, 2012·Blood·Sophie Georgin-LavialleGandhi Damaj
May 2, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Gerhard J MolderingsLawrence B Afrin
Aug 5, 2017·Postgraduate Medicine·Michelle LeMoshe Ben-Shoshan
Oct 20, 2017·British Journal of Haematology·Robyn M Scherber, Uma Borate

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.