Successful treatment of life-threatening Candida peritonitis in a child with abdominal non-Hodgkin lymphoma using Efungumab and amphotericin B colloid dispersion

Journal of Pediatric Hematology/oncology
Zdenka KrenovaJaroslav Sterba

Abstract

Invasive fungal infections are serious complications of cancer therapy. We present a case report of a 12-year-old boy diagnosed with abdominal non-Hodgkin lymphoma and fecal and Candida peritonitis during induction chemotherapy. The invasive mycosis was managed using a combined approach of systemic antifungal agents including efungumab and surgical interventions. Efungumab, a recombinant antibody that inhibits extracellular heat shock protein 90, was used in combination with amphotericin B colloid dispersion after the failure of standard approaches.

References

Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R WingardUNKNOWN L Amph/ABLC Collaborative Study Group
Mar 8, 2005·Journal of Pediatric Hematology/oncology·Galit P RosenTheodore B Moore
Jun 28, 2005·Current Molecular Medicine·R C Matthews, J P Burnie
Apr 19, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jan PachlUNKNOWN Mycograb Invasive Candidiasis Study Group
Jun 15, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M E FalagasV D Pappas

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Citations

Jul 24, 2013·Clinical & Developmental Immunology·Francesca BugliFrancesco Paroni Sterbini
Jan 1, 2013·ISRN Preventive Medicine·M Anaul Kabir, Zulfiqar Ahmad
Nov 29, 2014·BMC Infectious Diseases·Lara Zafrani, Elie Azoulay
Jun 11, 2015·Immunologic Research·Shusheng GengBeifen Shen
May 1, 2013·Expert Review of Anti-infective Therapy·Nevin Hatipoglu, Husem Hatipoglu
Oct 9, 2014·Mycoses·Brad MoriyamaScott R Penzak

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