PMID: 6170420Dec 1, 1981Paper

Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood

Cancer
W J ThomasB Duval-Arnould

Abstract

Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3 1/2 years after metastasis and 2 1/2 years after stopping therapy. The main toxic reactions encountered were associated with the use of cis-platinum, but these were manageable and resolved upon completion of therapy. Cis-VAB appears to be a safe and effective regimen for the treatment of metastatic endodermal sinus tumor. A study of the efficacy of cis-VAB in a larger group of children with endodermal sinus tumor of poor prognosis seems indicated.

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Citations

Dec 1, 1982·Journal of Pediatric Surgery·M M OlsenE R Morgan
Jan 1, 1991·Medical and Pediatric Oncology·P R BrockJ Pritchard
Sep 1, 1996·Journal of Pediatric Surgery·M UchiyamaY Yamato
Dec 1, 1983·Cancer Treatment Reviews·D M Green
Sep 1, 1985·Current Problems in Cancer·J L Grosfeld, D F Billmire
Jun 1, 1984·Journal of Pediatric Surgery·M KekomäkiP Vilkki
Jan 1, 1988·Medical and Pediatric Oncology·D SinniahR Nuruddin
Jan 1, 1984·Medical and Pediatric Oncology·I R BeddisM G Mott
Jan 1, 1983·Medical and Pediatric Oncology·M LopezA Barduagni
Apr 1, 1985·The Journal of Pediatrics·R B WomerT M Barratt
Jun 1, 1985·The Journal of Urology·W L CarrollM P Link
Jan 1, 1986·Medical and Pediatric Oncology·G B GaleT R Weber

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