Successful treatment of primary central nervous system lymphomas with chemotherapy after osmotic blood-brain barrier opening

Neurosurgery
E A NeuweltE P Frenkel

Abstract

Three patients with primary central nervous system (CNS) lymphoma have had major tumor regression with multiagent chemotherapy given in association with reversible blood-brain barrier opening used to enhance drug delivery to the tumor. In addition, in one patient barrier modification was carried out in the posterior fossa by mannitol infusion into the vertebral artery without untoward effects, an approach not heretofore accomplished. Computed tomographic (CT) studies documented that discontinuation of steroids rapidly effected an increase in the delivery of contrast agent to the tumor. CT monitoring of the degree of barrier modification showed tumor nodules and tumor size not apparent on the control scans, thereby providing additional evidence of the existence of a blood-brain barrier in CNS tumors. These studies further show that drug (contrast) delivery to the tumor, as well as to the surrounding barrier, is enhanced after reversible blood-brain barrier modification. Finally, chemotherapy administered by this approach resulted in defined, objective tumor responses in these three patients.

Citations

Apr 1, 1996·Journal of Neuro-oncology·S DentD J Stewart
Jan 1, 1995·Neurosurgical Review·K SharmaS Hukku
Feb 1, 1997·Italian Journal of Neurological Sciences·A Boiardi, A Silvani
Jun 1, 1988·Italian Journal of Neurological Sciences·G TrapellaL Cavazzini
Jan 1, 1987·Pharmacology & Therapeutics·V Bocci
Sep 1, 1994·Journal of the Autonomic Nervous System·T NagashimaN Tamaki
Dec 29, 1995·Neuroscience Letters·J D RichmonL J Noble
Jan 1, 1984·Cancer Drug Delivery·M K SpigelmanJ F Holland
Mar 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O Z ChiH R Weiss
Apr 1, 1985·Journal of Neurosurgery·Y KawakamiA Nishimoto
Feb 1, 1986·Journal of Neurosurgery·J B BlacklockE H Oldfield
Sep 1, 1988·Journal of Neurosurgery·M SuzukiH Kudo
Jan 1, 1992·Journal of Neurosurgery·W A Hall, O Fodstad
May 1, 1992·Journal of Neurosurgery·W A HallO Fodstad
Dec 1, 1996·Journal of Neurosurgery·B ZünkelerE H Oldfield
Feb 22, 2002·Biochemical and Biophysical Research Communications·Mitsuru IkedaNorihiko Tamaki
Nov 15, 1986·American Journal of Ophthalmology·R H MillayE A Neuwelt
Jun 20, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ichio AokiShoji Naruse
Sep 3, 2010·International Journal of Imaging Systems and Technology·Victor S LelyveldAlan Jasanoff
Sep 1, 1995·Cancer Treatment Reviews·A J FerreriE Villa
Mar 1, 1989·Cancer Treatment Reviews·D J Stewart, W K Evans
Jul 1, 1993·Cancer Treatment Reviews·G J Lesser, S A Grossman
May 1, 1990·Experimental Neurology·I F Pollack, R D Lund
Oct 1, 1986·Journal of Surgical Oncology·S T VakiliR L Campbell
Feb 24, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Tony R WangW Jeff Elias

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.