Successful Treatment of Primary Cutaneous Peripheral T-Cell Lymphoma Presenting Acquired Ichthyosis with Oral Bexarotene Monotherapy

Case Reports in Oncology
Kayo TanitaSetsuya Aiba

Abstract

Acquired ichthyosis (AI) is a reactive cutaneous manifestation that can be associated with malignant hematological disease, including cutaneous T-cell lymphoma (CTCL). Since it is difficult to distinguish AI from ichthyosiform mycosis fungoides, to select the treatment for CTCL with ichthyosis-like appearance and to evaluate its efficacy is sometimes challenging. In this report, we describe a case of primary cutaneous peripheral T-cell lymphoma not otherwise specified presenting AI successfully treated with oral bexarotene. In the present case, the administration of oral bexarotene was not only effective for lymphoma cells infiltrating ulcers and nodules, but it also eliminated AI.

References

May 1, 1996·Journal of the American Academy of Dermatology·B KüttingG Bonsmann
Apr 9, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Angelo V MarzanoElvio Alessi
Sep 27, 2003·The British Journal of Dermatology·M E J FranssenP C M Van De Kerkhof
Feb 28, 2004·Journal of the American Academy of Dermatology·Emmilia HodakMichael David
Mar 23, 2005·Archives of Dermatology·Jeanne B BudginAlain H Rook
May 7, 2009·The British Journal of Dermatology·S MorizaneK Iwatsuki
May 2, 2014·The Journal of Investigative Dermatology·Xuesong WuSam T Hwang
Feb 14, 2015·OncoTargets and Therapy·Manisha R Panchal, Julia J Scarisbrick
Jun 14, 2016·Journal of Dermatological Science·Taku FujimuraSetsuya Aiba

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Citations

Apr 11, 2018·BMJ Case Reports·Kundan MishraPankaj Malhotra
Sep 10, 2019·International Journal of Dermatology·Héctor Perandones GonzálezManuel Á Rodríguez Prieto

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Methods Mentioned

BETA
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