Successful treatment of progressive stage 4s hepatic neuroblastoma in a neonate with intra-arterial chemoembolization

Pediatric Blood & Cancer
Michael WeintraubArnold I Freeman

Abstract

Stage 4s neuroblastoma (NB) is a unique entity seen in infants less than 1 year of age, with metastatic disease confined to liver, skin, or bone marrow. Despite metastatic spread, stage 4s NB has a favorable outcome. An exception to this is seen in neonates who present with progressive enlargement of the liver with secondary respiratory compromise and liver failure. We describe a 4-week-old neonate who presented with 4s NB, with a rapidly enlarging liver, resulting in respiratory and hepatic failure, who had a rapid, sustained, and ongoing response to chemoembolization of the hepatic artery. This approach is feasible at this age, and may be effective in improving the outcome in this group of patients.

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Citations

Dec 2, 2015·Oncology Letters·Jing-Bo ShaoHui Jiang
Feb 22, 2011·Techniques in Vascular and Interventional Radiology·David J E Lord, S Murthy Chennapragada
Nov 16, 2012·Pediatric Blood & Cancer·Melanie SteeleSylvain Baruchel
May 19, 2012·Pediatric Blood & Cancer·Michael WeintraubShoshana Revel-Vilk
Jan 14, 2017·Pediatric Hematology and Oncology·Till HolstenMichael C Frühwald
Jan 13, 2019·Italian Journal of Pediatrics·Bruno De BernardiRiccardo Haupt
Jul 25, 2015·World Journal of Hepatology·Israel Fernandez-PinedaAndrew M Davidoff
Oct 31, 2020·Pediatric Surgery International·Stefano AvanziniBruno De Bernardi

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