Successful treatment of recurrent small bowel adenocarcinoma by cytoreductive surgery and chemotherapy: a case report and review of the literature.

Journal of Medical Case Reports
Tomoki YamanoKatsuyuki Aozasa

Abstract

Small bowel adenocarcinoma is a rare malignancy associated with a poor prognosis and there is little evidence of effective treatment. Recurrent small bowel adenocarcinoma is an intractable disease for which there is little information available regarding its treatment by palliative therapy. We present a case of recurrent small bowel adenocarcinoma successfully treated by cytoreductive surgery and palliative chemotherapy. We report the case of a 72-year-old Japanese female who developed a peritoneal metastasis from recurrent small bowel adenocarcinoma after curative resection and adjuvant chemotherapy with S-1 and polysaccharide K. She underwent cytoreductive surgery followed by chemotherapy with folinic acid/fluorouracil/oxaliplatin and folinic acid/fluorouracil/irinotecan with polysaccharide K. Subsequently, no sign of a recurrence was observed 42 months after the second operation. To the best of our knowledge, this is the first case report of the successful treatment of peritoneal metastasis from small bowel adenocarcinoma by cytoreductive surgery and combination chemotherapy (folinic acid/fluorouracil/oxaliplatin and folinic acid/fluorouracil/irinotecan with polysaccharide K).

References

Aug 1, 1986·The Surgical Clinics of North America·R G Martin
Mar 1, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P Marchettini, P H Sugarbaker
Sep 1, 2005·Cancer Immunology, Immunotherapy : CII·Junichi SakamotoUNKNOWN Meta-Analysis Group of the Japanese Society for Cancer of the Colon Rectum
Nov 12, 2005·Oncology·Christophe LocherMichel Ducreux
Nov 16, 2006·Cancer Immunology, Immunotherapy : CII·Koji ObaJunichi Sakamoto
Jul 20, 2007·The Cochrane Database of Systematic Reviews·N Singhal, D Singhal
Nov 6, 2007·The New England Journal of Medicine·Shinichi SakuramotoUNKNOWN ACTS-GC Group
Jan 24, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael J OvermanRobert A Wolff

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BETA
hysterectomy

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