Successful treatment of refractory Langerhans cell histiocytosis with unrelated cord blood transplantation

Journal of Pediatric Hematology/oncology
R NagarajanK S Baker

Abstract

A 2-month-old girl presented for treatment with a diffuse rash, interstitial pneumonia, otorrhea, and lymphadenopathy. Skin biopsy confirmed Langerhans cell histocytosis by electron microscopy. After receiving multiple courses of chemotherapy, only marginal improvement was achieved, with progressive marrow and liver involvement. The decision was made to pursue a human leukocyte antigen-identical unrelated cord blood transplantation. Two years after transplant, the bone marrow was clear of Langerhans cell histocytosis and 100% donor engraftment. The poor prognosis of patients with an inadequate response to therapy and the presence of organ dysfunction (marrow and liver) substantiated the decision to pursue an unrelated cord blood transplantation.

References

Jan 1, 1994·Medical and Pediatric Oncology·H GadnerS Ladisch
Nov 26, 1998·The New England Journal of Medicine·P RubinsteinC E Stevens

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Citations

Oct 10, 2006·Skeletal Radiology·Kevin Bradford HooverHenry Mankin
Apr 18, 2003·Lancet·John C LeonidasElsa Valderrama
May 8, 2007·Journal of Pediatric Hematology/oncology·Rong-Long ChenPao-Lin Kuo
Apr 21, 2011·Pediatric Dermatology·Hart Isaacs
Apr 29, 2014·The Journal of Surgical Research·Samuel GolpanianSeth R Thaller
Nov 7, 2007·Neuroradiology·Philippe Demaerel, Stefaan Van Gool
Nov 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F BernardJ Donadieu
May 3, 2006·Pediatric Hematology and Oncology·Judit MüllerUNKNOWN Hungarian Pediatric Oncology Network
Nov 25, 2004·Hematology·Kenneth L McClainSteven H Swerdlow
Feb 21, 2019·International Journal of Oral Science·En LuoQianming Chen
Nov 1, 2007·Expert Review of Endocrinology & Metabolism·Polyzois MakrasGregory A Kaltsas
Feb 16, 2006·Actas dermo-sifiliográficas·Marta Valdivielso, Celso Bueno

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