Abstract
Given the heterogeneity of published data in US children, we sought to evaluate outcomes of a standardized immunosuppressive therapy (IST) regimen for severe aplastic anemia (SAA) at The Children's Hospital (Denver, CO). We retrospectively analyzed the records of 16 children diagnosed from 1990 to 2003 and treated by IST, among whom 14 received the standardized regimen of antithymocyte globulin (ATG) and cyclosporine A (CsA). Serial hematologic parameters, complications, transfusion requirements, and time to response were assessed. One child who died from a pre-existing Aspergillus infection prior to expected IST response was excluded from the analysis. Overall (transfusion-independent) response to IST was 100% (13/13), without any relapses or clinically evident leukemic/myelodysplastic transformations after a median follow-up time of 4.4 years (range: 10 months-13.3 years). This report documents excellent outcome using combination ATG and CsA IST for pediatric SAA.
References
Jan 1, 1997·British Journal of Haematology·J J MelenhorstJ E Landegent
May 8, 1997·The New England Journal of Medicine·N S Young, J Maciejewski
Mar 1, 1997·Journal of Pediatric Hematology/oncology·E R LawlorK R Schultz
Sep 23, 1998·Klinische Pädiatrie·M FührerC Bender-Götze
Jun 10, 2000·British Journal of Haematology·O PfisterA Wodnar-Filipowicz
Jan 10, 2001·Bone Marrow Transplantation·M FouladiM H Freedman
Dec 12, 2001·British Journal of Haematology·J ScopesF M Gibson
Oct 24, 2002·Blood·Norbert FrickhofenUNKNOWN German Aplastic Anemia Study Group
Nov 15, 2002·International Journal of Hematology·Seiji Kojima
Mar 8, 2003·JAMA : the Journal of the American Medical Association·Stephen RosenfeldNeal S Young
Citations
Jun 11, 2005·European Journal of Pediatrics·Lucien Corbeel
Nov 7, 2012·Journal of Pediatric Hematology/oncology·Katharine BrockTaru Hays
May 20, 2014·Cellular Immunology·Lin-na XieFang Zhou
Mar 10, 2012·Journal of Cancer Research and Clinical Oncology·Chun ChenShao-Liang Huang
Oct 27, 2004·Pediatric Blood & Cancer·Robert Brodsky
Feb 12, 2005·Pediatric Blood & Cancer·Peter KurreH Joachim Deeg
Jan 17, 2009·Pediatric Blood & Cancer·Abdulrahman AlsultanTaru Hays
Jan 13, 2015·American Journal of Hematology·Craig M ForesterInga Hofmann
Oct 15, 2009·Pediatric Blood & Cancer·Anthony N AudinoJeffrey D Hord
Feb 8, 2014·PloS One·Huaquan WangZonghong Shao
Mar 4, 2014·Experimental Hematology·Xiaotian XieXiaohong Qiao
May 9, 2012·Transplantation Proceedings·M UchiyamaM Niimi
Jun 17, 2014·Blood Cells, Molecules & Diseases·Xianmin ZhuYicheng Zhang
Aug 18, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Miranda Hall, Tracy M Hagemann
Feb 13, 2018·Experimental and Therapeutic Medicine·Xiu LuoYi Ding
Mar 9, 2021·Curēus·Emily Van AntwerpRyan McCarthy