Successful treatment of severe crescentic lupus nephritis by multi-target therapy using tacrolimus and mycophenolate mofetil

CEN Case Reports
Kaori MochizukiYoshihisa Nojima

Abstract

Treatment of severe lupus nephritis (LN) has been controversial, and according to recent guidelines and recommendations, cyclophosphamide still remains a first-line therapy. Herein, we present the case of a 37-year-old female patient who developed rapidly progressive glomerulonephritis, which was histologically diagnosed as class IV + V LN, with a large number of cellular to fibrocellular crescents (62 % of glomeruli). Although the patient was considered to have the most severe form of LN, complete remission was achieved within 6 months by multi-target therapy using tacrolimus and mycophenolate mofetil combined with methylprednisolone pulse therapy. Our experience suggests that multi-target therapy could be a potential treatment option for patients with severe crescentic LN.

References

Jul 4, 2008·Journal of the American Society of Nephrology : JASN·Hao BaoLei-Shi Li
May 5, 2012·Arthritis Care & Research·Bevra H HahnUNKNOWN American College of Rheumatology
Aug 2, 2012·Annals of the Rheumatic Diseases·George K BertsiasUNKNOWN European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association
Aug 11, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Brad H RovinNeil Solomons
Nov 20, 2013·American Journal of Nephrology·Shasha ChenZhihong Liu
Jan 3, 2014·International Journal of Rheumatic Diseases·Chi Chiu MokUNKNOWN Asian Lupus Nephritis Network (ALNN)

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